Anmol Chemicals is the pioneer manufacturers of HEDP Phosphonate or Hydroxyethylidene Diphosphonic Acid, Pharmaceutical Excipients Fragrance & Flavor chemicals in India. We offer Halal and Kosher HEDP Phosphonate made in an ISO9001:2008, ISO22000:2005 (FSSC22000) and cGMP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Hydroxyethylidene Diphosphonic Acid is in these pages. The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal
HEDP, Hydroxyethylidene Diphosphonic Acid SDS GHS, MSDS Sheet
Hydroxyethylidene Diphosphonic Acid (HEDP Phosphonate) SDS, MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Synonyms: Sal HEDP Phosphonate; HEDP (A); HEDPA; ETIDRONIC ACID;1-Hydroxy Ethylidene-1,1-Diphosphonic Acid; Hydroxyethylidene-1,1-diphosphonicacid(HEDP); 1-HYDROXYETHYLIDENEDIPHOSPHONIC ACID; Hydroxyethylidene Diphosphonic acid (HEDP);1-hydroxy-1,1-Ethanediyl ester
CAS No.: 2809-21-4
EINECS EC Number: 220-552-8
Molecular Weight: 206.02
Chemical Formula: C2H8O7P2
Recommended usage: Industrial Manufacturing.
Suppliers: As per letterhead above.
2. Hazards Identification
Corrosive to Metals Category 1
Acute Toxicity: Oral, Category 4
Skin Corrosion/Irritation, Category 1A B C
Hazardous to the aquatic environment, acute hazard Category 2
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Labeling according Regulation (EC) No 1272/2008
GHS Label Elements
Signal Words: Danger
H290: May be corrosive to metals.
H302: Harmful if swallowed.
H314: Causes severe skin burns and eye damage.
H401: Toxic to aquatic life.
P234: Keep only in original container.
P260: Do not breathe.
P264: Wash hands thoroughly after handling.
P280: :Wear protective gloves/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P301+P330+P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P363: Wash contaminated clothing before reuse.
P404: Store in a closed container.
P405: Store locked up.
P390: Absorb spillage to prevent material damage.
P501: Dispose of contents/container through a waste management company authorized by the local government.
Classification according to Regulation (EC) No 1272/2008:
Corrosive to Metals Category 1 (H290)
Acute Toxicity: Oral, Category 4 (H302)
Skin Corrosion/Irritation, Category 1A B C (H314)
Hazardous to the aquatic environment, acute hazard Category 2 (H401)
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
C Corrosive; R34 Causes burns; R 22-36-38 Harmful if swallowed. Irritating to eyes. Irritating to skin
For the full text of the H-Statements & R-phrases mentioned in this Section, see Section 16.
3. Composition/Information on Ingredients
Ingredient: 1-Hydroxyethylidene-1, 1-Diphosphonic Acid or HEDP 58-62% in water
CAS No.: 2809-21-4
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion: Do not induce vomiting. Get medical attention immediately.. Never give anything by mouth to an unconscious person.
Skin: Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Do not allow the victim to rub eyes. Get medical attention.
5. Fire Fighting Measures
Fire: 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid or HEDP Phosphonate is a slight fire hazard. Dust air mixture may ignite or explode.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire over HEDP. Water spray may be used to keep fire exposed containers cool. Dry chemicals, carbon dioxide, water, foam are ok.
Special Information: In the event of a fire over HEDP, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust dispersal. Do not release 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid or HEDP in to sewer.
7. Handling and Storage
Keep HEDP in a tightly closed container. Protect from physical damage. Store in a cool, dry, ventilated area away from sources of heat, moisture and incompatibilities. Do not ingest or inhale and avoid contact. Containers of 1-Hydroxyethylidene-1,1-Diphosphonic Acid or HEDP Phosphonate may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Exposure Limits: No occupational exposure limits established.
Ventilation: Provide local exhaust ventilation system. Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Ensure compliance with applicable exposure limits.
Eye Protection: Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area.
Clothing: Wear appropriate chemical resistant clothing.
Protective Material Type: Rubber
Respirator: Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Use any dust, mist and fume respirator. Any air-purifying respirator with a high-efficiency particulate filter. Any powered, air-purifying respirator with a dust, mist and fume filter. Any powered, air-purifying respirator with a high-efficiency particulate filter.
9. Physical and Chemical Properties
Physical State: 1-Hydroxyethylidene-1,1-Diphosphonic Acid or HEDP is liquid
Appearance: Clear, colorless to pale straw
Molecular Formula: C-H3-C-(H2-O3-P) 2-O-H
Boiling Point: 108C, 226F
Melting point: < 1C, < 34F
Specific gravity: 1.40 - 1.45
pH:2 - 3
Vapor Pressure: 23.8 @ 25C, 77F
Vapor Density: 0.8
Decomposition Temperature: Unknown
Evaporation Rate: 1 (N-Butyl Acetate = 12)
Water solubility: Complete
10. Stability and Reactivity
Reactivity: 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid or HEDP Phosphonate is stable at normal temperature and pressure.
Conditions to avoid: Avoid heat, flames, sparks and other sources of ignition. Dangerous gases may accumulate in confined spaces. May ignite or explode on contact with combustible materials.
Incompatibilities: Bases, amines, metals, reducing agents, oxidizing materials.
Alkalies: Violent reaction
Metals: May be corrosive in the presence of moisture
Metal salts of sulfides: May release toxic gases
Oxidizers: Fire and explosion hazard
Sulfites: May release toxic gases
Hazardous Decomposition: Thermal decomposition products: phosphine, inorganic acids, oxides of phosphorus.
Polymerization: Will not occur.
11. Toxicological Information
1800 mg/kg oral-mouse LD50
Local effects: Irritant skin, eye corrosive, inhalation ingestion.
Toxicity: Moderately toxic: ingestion
40 mg/kg intraperitoneal-mouse TDLo 7 day/s pregnant female continuous;
200 mg/kg intraperitoneal-mouse TDLo 7 day/s pregnant female continuous;
200 mg/kg intraperitoneal-mouse TDLo 7 day/s pregnant female continuous;
200 mg/kg intraperitoneal-mouse TDLo 8 day/s pregnant female continuous;
200 mg/kg subcutaneous-mouse TDLo 13 day/s pregnant female continuous;
1400 mg/kg subcutaneous-mouse TDLo 11-17 day/s pregnant female continuous.
Carcinogenicity: 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid is not known to be carcinogen.
12. Ecological Information
Environmental Toxicity: Invertebrates: 48 h, EC50 Water flea (Daphnia magna) 527 mg/l Fish: 96 h, LC50 Rainbow trout (Oncorhynchus mykiss) 368 mg/l 96 h, LC50 Bluegill sunfish (Lepomis macrochirus) 868 mg/l
Algae: 96 h, EC50 Algae (Selenastrum capricornutum) 3 mg/l
Algal growth inhibition is due to ability of this product to complex materials not to toxicity per se.
Modified OECD Screening theoretical CO2 evolution 2 % 70 d Modified SCAS Dissolved Organic Carbon removed 90 % Closed Bottle BOD30/COD 5 %
Degrades after acclimatization. Not expected to bio-accumulate.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of 1-Hydroxyethylidene-1,1-Diphosphonic Acid or HEDP Phosphonate container and unused contents in accordance with federal, state and local requirements.
14. Transport Information
DOT USA Proper Shipping Name : Corrosive liquid, acidic, organic, n.o.s. (phosphonic acid)
DOT Class : 8
DOT ID Number : UN 3265
DOT Pack Group : III
DOT Label : Corrosive
IMO Proper Shipping Name : Corrosive liquid, acidic, organic, n.o.s. (phosphonic acid)
IMO UN Number : 3265
IMO UN Class : 8
IMO Subsidiary Risk Label : -
IATA UN ID Number : 3265
IATA Proper Shipping Name : Corrosive liquid, acidic, organic, n.o.s. (phosphonic acid)
IATA Label : Corrosive
AFI Proper Shipping Name : Corrosive liquid, acidic, organic, n.o.s.
AFI Class : 8
AFI ID Number : UN 3265
AFI Pack Group : III
AFI Label : Corrosive
n.o.s. Shipping Name : 1-Hydroxyethylidene-1,1-Diphosphonic Acid
15. Regulatory Information
TSCA Status : Y
TSCA 12(b) export notification : Not listed
CERCLA Section 103 (40 CFR 302.4) : N
SARA Section 302 (40 CFR 355.30) : N TPQ
SARA Section 304 (40 CFR 355.40) : N RQ
SARA Section 313 (40 CFR 372.65) : N
California Prop 65 Status : N
SARA Acute Hazard : Y
SARA Chronic Hazard : N
SARA Fire Hazard : N
SARA Reactivity Hazard : N
SARA Sudden Release Hazard : N
Canada WHMIS Classification : D2B, E.
EINECS EC Number: 220-552-8
Hazard Symbol: C Corrosive
R : 22-36-38
Harmful if swallowed. Irritating to eyes. Irritating to skin.
R34: Causes burns.
S : 2-13-24-25-26-36-46
Keep out of reach of children. Keep away from food, drink and animal feeding stuffs. Avoid contact with skin. Avoid contact with eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. If swallowed, seek medical advice immediately and show this container or label.
Section 16 - Additional Information
H290 = May be corrosive to metals.
H302 = Harmful if swallowed.
H314 = Causes severe skin burns and eye damage.
H401 = Toxic to aquatic life.
C = Corrosive
R 22-36-38 = Harmful if swallowed. Irritating to eyes. Irritating to skin.
R34 = Causes burns.
Our company provides this 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid or HEDP Phosphonate SDS information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. HEDP or 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
Hydroxy Ethylidene Diphosphonic Acid manufacturers;
Hydroxyethylidene Diphosphonic Acid manufacturers HEDP Phosphonate manufacturers:
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564 - FAX: 91-22-23728264
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Hydroxyethylidene or Hydroxy Ethylidene Diphosphonic Acid, HEDP Phosphonate Manufacturers